ABHD12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0052651Biological processmonoacylglycerol catabolic process
GO_0007628Biological processadult walking behavior
GO_0098734Biological processmacromolecule depalmitoylation
GO_0010996Biological processresponse to auditory stimulus
GO_0050727Biological processregulation of inflammatory response
GO_0006660Biological processphosphatidylserine catabolic process
GO_0046464Biological processacylglycerol catabolic process
GO_0046475Biological processglycerophospholipid catabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0009395Biological processphospholipid catabolic process
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032281Cellular componentAMPA glutamate receptor complex
GO_0032839Cellular componentdendrite cytoplasm
GO_0004620Molecular functionphospholipase activity
GO_0004622Molecular functionlysophospholipase activity
GO_0008474Molecular functionpalmitoyl-(protein) hydrolase activity
GO_0047372Molecular functionacylglycerol lipase activity

IV. Literature review

[source]
Gene nameABHD12
Protein nameLysophosphatidylserine lipase ABHD12 (EC 3.1.-.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (hABHD12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-)
Abhydrolase domain containing 12, lysophospholipase
Lysophosphatidylserine lipase ABHD12 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (Monoacylglycerol lipase ABHD12) (Oxidized phosphatidylserine lipase ABHD12)
SynonymsC20orf22
DescriptionFUNCTION: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes . Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal . Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways . Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding . .

AccessionsENST00000576316.5
I3L380
ENST00000339157.10 [Q8N2K0-1]
ENST00000671784.1
A0A5F9ZGT4
ENST00000376542.8 [Q8N2K0-2]
ENST00000471287.5
ENST00000673121.1
ENST00000672258.1
I3L206
ENST00000673227.1
ENST00000672114.1
A0A5F9ZGZ9
I3L294
A0A5F9ZH49
ENST00000671858.1
A0A5F9ZGW7
ENST00000450393.5
A0A5F9ZHG5
A0A5F9ZHM3
I3L440
ENST00000672358.1
A0A5F9ZHF0
ENST00000672331.1
ENST00000491682.5
ENST00000672406.1
Q5T712
A0A5F9ZHQ8
A0A5F9ZHH2
ENST00000673524.1
ENST00000672596.1
I3L1V0
ENST00000673094.1
ENST00000465694.2
Q8N2K0
A0A5F9ZHE8
A0A5F9ZHQ0
A0A5F9ZH71
ENST00000461204.1
ENST00000672566.1
A0A5F9ZH28
A0A5F9ZHB5
ENST00000672871.1