ABCC3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
epithelial cell	10 studies	27% ± 8%	Explore
macrophage	7 studies	25% ± 6%	Explore
goblet cell	6 studies	23% ± 6%	Explore
platelet	6 studies	29% ± 11%	Explore
basal cell	6 studies	27% ± 12%	Explore
hepatocyte	5 studies	53% ± 26%	Explore
cholangiocyte	4 studies	66% ± 21%	Explore
abnormal cell	4 studies	17% ± 1%	Explore
type I pneumocyte	4 studies	21% ± 4%	Explore
alveolar macrophage	4 studies	35% ± 13%	Explore
non-classical monocyte	3 studies	25% ± 7%	Explore
megakaryocyte	3 studies	34% ± 13%	Explore
astrocyte	3 studies	32% ± 18%	Explore
club cell	3 studies	26% ± 5%	Explore
monocyte	3 studies	28% ± 12%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCC3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	16819.00	226 / 226	94%	62.54	381 / 406
pancreas	100%	9393.56	327 / 328	93%	92.43	165 / 178
stomach	88%	8843.74	316 / 359	94%	52.91	270 / 286
lung	99%	3970.07	571 / 578	80%	55.93	919 / 1155
kidney	90%	4993.62	80 / 89	86%	62.46	772 / 901
thymus	83%	4941.93	544 / 653	75%	30.33	455 / 605
intestine	56%	8183.27	537 / 966	98%	58.50	514 / 527
bladder	71%	4892.86	15 / 21	76%	38.10	381 / 504
adrenal gland	100%	36773.08	258 / 258	34%	13.90	78 / 230
esophagus	44%	1783.84	637 / 1445	78%	56.41	142 / 183
breast	75%	3681.70	343 / 459	38%	9.56	427 / 1118
prostate	91%	6974.18	222 / 245	14%	1.73	68 / 502
skin	99%	5551.76	1796 / 1809	4%	0.71	19 / 472
ureter	0%	0	0 / 0	100%	13.54	1 / 1
spleen	95%	2755.80	230 / 241	0%	0	0 / 0
blood vessel	72%	2990.71	957 / 1335	0%	0	0 / 0
adipose	62%	1333.59	752 / 1204	0%	0	0 / 0
uterus	21%	396.52	35 / 170	40%	15.23	183 / 459
lymph node	0%	0	0 / 0	38%	4.90	11 / 29
ovary	22%	357.61	40 / 180	12%	2.23	51 / 430
peripheral blood	27%	402.00	248 / 929	0%	0	0 / 0
brain	1%	13.22	23 / 2642	25%	9.71	175 / 705
tonsil	0%	0	0 / 0	16%	2.86	7 / 45
heart	6%	100.53	53 / 861	0%	0	0 / 0
muscle	1%	11.09	5 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006805	Biological process	xenobiotic metabolic process
GO_0006855	Biological process	xenobiotic transmembrane transport
GO_0098656	Biological process	monoatomic anion transmembrane transport
GO_0055085	Biological process	transmembrane transport
GO_0150104	Biological process	transport across blood-brain barrier
GO_0015779	Biological process	glucuronoside transport
GO_0015721	Biological process	bile acid and bile salt transport
GO_0042908	Biological process	xenobiotic transport
GO_0071716	Biological process	leukotriene transport
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0009925	Cellular component	basal plasma membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0071714	Molecular function	icosanoid transmembrane transporter activity
GO_0140359	Molecular function	ABC-type transporter activity
GO_0043225	Molecular function	ATPase-coupled inorganic anion transmembrane transporter activity
GO_0015432	Molecular function	ABC-type bile acid transporter activity
GO_0008559	Molecular function	ABC-type xenobiotic transporter activity
GO_0015431	Molecular function	ABC-type glutathione S-conjugate transporter activity
GO_0042910	Molecular function	xenobiotic transmembrane transporter activity
GO_0005524	Molecular function	ATP binding
GO_0042626	Molecular function	ATPase-coupled transmembrane transporter activity
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0015164	Molecular function	glucuronoside transmembrane transporter activity

IV. Literature review

[source]

Gene name	ABCC3
Protein name	ABCC3 protein ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3) ATP binding cassette subfamily C member 3
Synonyms	CMOAT2 MRP3 MLP2
Description	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes . Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) . Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells . .
Accessions	ENST00000427699.5 [O15438-5] D6RAB7 Q2M3C9 O15438 ENST00000510633.5 ENST00000513745.1 ENST00000502426.5 [O15438-3] H0Y8T5 ENST00000513511.5 ENST00000515585.1 ENST00000515707.1 ENST00000505699.5 [O15438-2] D6RJE5 H0Y8Q6 Q86VN9 H0Y9T4 ENST00000285238.13 [O15438-1]

ABCC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review