ABCC11 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ABCC11 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCC11 at tissue level.

III. Associated gene sets

GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0055085Biological processtransmembrane transport
GO_0015721Biological processbile acid and bile salt transport
GO_0042908Biological processxenobiotic transport
GO_0015711Biological processorganic anion transport
GO_0015865Biological processpurine nucleotide transport
GO_0071716Biological processleukotriene transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005774Cellular componentvacuolar membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0043225Molecular functionATPase-coupled inorganic anion transmembrane transporter activity
GO_0015432Molecular functionABC-type bile acid transporter activity
GO_0008559Molecular functionABC-type xenobiotic transporter activity
GO_0015431Molecular functionABC-type glutathione S-conjugate transporter activity
GO_0015216Molecular functionpurine nucleotide transmembrane transporter activity
GO_0005524Molecular functionATP binding
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCC11
Protein nameATP binding cassette subfamily C member 11
ATP-binding cassette sub-family C member 11 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 8)
SynonymsMRP8
DescriptionFUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Plays a role in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides, including cAMP and cGMP . Mediates the ATP-dependent efflux of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates, such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate . Plays a role in the transport of earwax components . Participates in the secretion of odorants and their precursors from the apocrine sweat glands, including the secretion of glutamine conjugates, as well as the Cys-Gly-(S) conjugates of 3-methyl-3-sulfanyl-hexanol . Involved in the cellular extrusion of nucleotide analogs, hence confering resistance to various drugs, including clinically relevant drugs such as 5-fluorouracil (5-FU) and methotrexate . .

AccessionsENST00000394747.5 [Q96J66-1]
ENST00000394748.5 [Q96J66-1]
ENST00000356608.7 [Q96J66-1]
H3BRJ2
Q96J66
ENST00000569991.1
ENST00000353782.9 [Q96J66-2]