AADAT report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AADAT at tissue level.

III. Associated gene sets

GO_0006536Biological processglutamate metabolic process
GO_0033512Biological processL-lysine catabolic process to acetyl-CoA via saccharopine
GO_0006103Biological process2-oxoglutarate metabolic process
GO_0070189Biological processkynurenine metabolic process
GO_0097052Biological processL-kynurenine metabolic process
GO_1901605Biological processalpha-amino acid metabolic process
GO_0009058Biological processbiosynthetic process
GO_0005759Cellular componentmitochondrial matrix
GO_0016212Molecular functionkynurenine-oxoglutarate transaminase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0047958Molecular functionglycine:2-oxoglutarate aminotransferase activity
GO_0047536Molecular function2-aminoadipate transaminase activity
GO_0050094Molecular functionmethionine-glyoxylate transaminase activity
GO_0047315Molecular functionkynurenine-glyoxylate transaminase activity
GO_0030170Molecular functionpyridoxal phosphate binding

IV. Literature review

[source]
Gene nameAADAT
Protein nameAminoadipate aminotransferase, isoform CRA_b (cDNA, FLJ95590, Homo sapiens L-kynurenine/alpha-aminoadipate aminotransferase (KATII), mRNA)
Aminoadipate aminotransferase
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Glycine transaminase AADAT) (EC 2.6.1.4) (Kynurenine aminotransferase II) (Kynurenine--glyoxylate transaminase AADAT) (EC 2.6.1.63) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II) (Methionine--glyoxylate transaminase AADAT) (EC 2.6.1.73)
SynonymsKYAT2
hCG_17308
KAT2
DescriptionFUNCTION: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). .

AccessionsENST00000502392.1
D6RC56
Q4W5N8
ENST00000353187.6 [Q8N5Z0-1]
ENST00000510340.5
ENST00000507375.5
ENST00000515480.5 [Q8N5Z0-1]
D6REB9
Q8N5Z0
ENST00000337664.9 [Q8N5Z0-1]
D6RFY7
ENST00000509167.5 [Q8N5Z0-2]