A2ML1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of A2ML1 at tissue level.

III. Associated gene sets

GO_0052548Biological processregulation of endopeptidase activity
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity
GO_0030414Molecular functionpeptidase inhibitor activity

IV. Literature review

[source]
Gene nameA2ML1
Protein nameAlpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9)
Alpha-2-macroglobulin like 1
SynonymsCPAMD9
DescriptionFUNCTION: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. .

AccessionsENST00000299698.12 [A8K2U0-1]
F5GYG7
H0YGG5
ENST00000545692.1
F5GXP1
ENST00000539547.5 [A8K2U0-2]
H0YH14
ENST00000537475.1
A8K2U0
ENST00000541459.5
ENST00000536789.5